周莹珊

周莹珊，博士，副教授。主要从事动物病毒与宿主相互作用研究，主要涉及猪流行性腹泻病毒和猪圆环病毒。

通讯地址
浙江省杭州市临安区武肃街666号
E-mail: yszhou@zafu.edu.cn
电话/传真：0571-61083275

教育背景
博士(2011/09-2016/06):浙江大学，动物科学学院，预防兽医学专业
学士(2006/09-2011/06):南京农业大学，动物医学院，动物医学专业

工作经历
2016/07 - 至今：浙江农林大学动物科技学院

研究方向
1.病毒与宿主的相互作用
2.分子病毒学与分子免疫学

科研项目
1.国家自然科学基金青年基金项目，31902249，猪圆环病毒2型通过内质网应激介导细胞凋亡的机制研究，2020.01-2022.12，24万元，主持。
2.浙江省重点研发计划项目，2019C02043，重大猪病毒性疾病高效疫苗及免疫技术研究与开发-猪瘟鉴别检测，2019.01-2021.12，80万元，主持。
3.浙江省自然科学基金青年基金项目，LQ19C180003，猪圆环病毒2型衣壳蛋白通过内质网应激CHOP蛋白介导的细胞凋亡机制研究，2019.01-2021.12，10万元，主持。

发表论文
1. Renjie Sun, Zhuofan Deng, Xiao Han, Yikai Zhang, Yingshan Zhou, Ying Shan, Weihuan Fang*, Xiaoliang Li*, Porcine circovirus 2 manipulates the PERK-ERO1a axis of the endoplasmic reticulum to favor its replication by derepressing viral DNA from HMGB1 sequestration within nuclei. Journal of virology,2021, 95(19), e01009-21.
2.Yingshan Zhou#, Lin Chen#, Lifei Zhang, Chunyan Shao, Jing Sun, Sheng Jiang, Quanjiang Song, Bin Zhou, Yongchun Yang, Wanyu Dong, Yang Yang, Fangfang Wei, Weihuan Fang, Xiaodu Wang*, Houhui Song*, Simultaneous Identification of 6 Pathogens Causing Porcine Reproductive Failure by Using Multiplex Ligation-Dependent Probe Amplification, Transbound Emerg Dis, 2020;67:2467–2474.
3.Renjie Sun, Siqi Sun, Yikai Zhang, Yingshan Zhou, Ying Shan, Xiaoliang Li*, Weihuan Fang*, PCV2 induces reactive oxygen species to promote nucleocytoplasmic translocation of the viral DNA binding protein HMGB1 to enhance its replication. Journal of virology, 2020, 94(13), e00238-20.
4.Yingshan Zhou#,Cong Chen#, Yunlu Chen, Ziqi Liu, Jingyou Zheng, Tingjun Wang, Hao Luo, Yajie Liu, Ying Shan, Weihuan Fang, Xiaoliang Li*, Effect of route of inoculation on innate and adaptive immune responses to porcine epidemic diarrhea virus infection in suckling pigs, Vet Microbiol, 2019, 228: 83~92.
5.Yuanxing Gu#,Yingshan Zhou#,Xinfeng Shi, Yongping Xin, Ying Shan, Cong Chen, Tong Cao, Weihuan Fang, Xiaoliang Li*, Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells, Arch Virol, 2018, 163(3): 623-632.
6.Li Gong, Baikui Wang, Xiaoqiang Mei, Han Xu, Yan Qin; Weifen Li*,Yingshan Zhou*,Effects of three probiotic Bacillus on growth performance, digestive enzyme activities, antioxidative capacity, serum immunity, and biochemical parameters in broilers, Anim Sci J, 2018, 89(11): 1561~1571.
7.Jing Sun #, Qunjing Li #, Chunyan Shao #, Yuanmei Ma, Haijian He, Sheng Jiang, Yingshan Zhou, Yuan Wu, Shaobo Ba, Lin Shi, Weihuan Fang, Xiaodu Wang *, Houhui Song *, Isolation and characterization of Chinese porcine epidemic diarrhea virus with novel mutations and deletions in the S gene, Vet Microbiol, 2018, 221: 81~89
8.Yang Wang, Wei Du, Kai Lei, Baikui Wang, Yuanyuan Wang, Yingshan Zhou, Weifen Li*, Effects of Dietary Bacillus licheniformis on Gut Physical Barrier, Immunity, and Reproductive Hormones of Laying Hens, Probiotics Antimicro, 2017, 9(3): 292-299.
9.Yingshan Zhou, Yuanxing Gu, Baozhu Qi, Yikai Zhang, Xiaoliang Li, Weihuan Fang*, Porcine Circovirus Type 2 Capsid Protein Induces Unfolded Protein Response with Subsequent Activation of Apoptosis, J Zhejiang Univ Sci b, 2017, 18(4): 316-323.
10.Yingshan Zhou, Baozhu Qi, Yuanxing Gu, Fei Xu, Huahua Du, Xiaoliang Li, Weihuan Fang*, Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its Enhanced Replication in PK-15 Cells, Viruses, 2016, 8(2): 56.
11.Yingshan Zhou#,Quan Liang#, Weifen Li, Yuanxing Gu, Xun Liao, Weihuan Fang, Xiaoliang Li*, Characterization and Functional Analysis of Toll-like Receptor 4 in Chinese Soft-shelled Turtle Pelodiscus sinensis, Dev Comp Immunol, 2016, 63: 128-135.
12.Yuanxing Gu, Baozhu Qi, Yingshan Zhou,Xiaowu Jiang, Xian Zhang, Xiaoliang Li, Weihuan Fang*, Porcine Circovirus Type 2 Activates CaMMKβ to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium, Viruses, 2016, 8(5): 135.
13.Quan Liang#, Weifen Li#, Ningning Guo, Chao Tong, Yingshan Zhou, Weihuan Fang, Xiaoliang Li*, Identification and Functional Analysis of Interleukin-1β in the Chinese Soft-Shelled Turtle Pelodiscus sinensis, Genes, 2016, 7(5): 18.
14.Xun Liao, Zuohuan Wang, Tong Cao, Chao Tong, Shichao Geng, Yuanxing Gu, Yingshan Zhou, Xiaoliang Li, Weihuan Fang*, Hypervariable Antigenic Region 1 of Classical Swine Fever Virus E2 Protein Impacts Antibody Neutralization, Vaccine, 2016, 34(33): 3723-3730.
15.Binglin Zhu, Yingshan Zhou, Fei Xu, Jiangbing Shuai, Xiaoliang Li, Weihuan Fang*, Porcine Circovirus Type 2 Induces Autophagy via the AMPK/ERK/TSC2/mTOR Signaling Pathway in PK-15 Cell, J Virol, 2012, 86(22): 12003-12012.
中文期刊
1.王雨萌†，周柯†，邵春艳，杨永春，周莹珊*，宋厚辉*，多重连接探针扩增技术(MLPA)在病原微生物检测与疾病诊断中的应用，2021, 29(10), 2031-2042.
2.周莹珊†，陈琳†，张丽菲，邵春艳，杨永春，黄保续，王晓杜*，宋厚辉*，禽呼吸道7种病毒多重连接探针扩增检测技术的建立与应用，中国兽医学报，2020, 40(12), 2311-2315+2319.
3.何海健†, 刘正奎†, 吴瑗, 王志鹏, 陈琳, 王磊, 周莹珊, 蒋春燕, 宋厚辉*, 王晓杜*. 猪病毒性腹泻病相关病原的MLPA检测技术的建立及应用[J]. 农业生物技术学报, 2020, 28(9): 1699-1710.
4.周莹珊†，陈琳†，孙静，姜胜，邵春艳，周彬，宋泉江，黄保续，王晓杜*，宋厚辉*，猪猝死症4种重要病原多重连接探针扩增鉴别检测技术的建立与应用[J], 中国预防兽医学报，2019,(02):161-167.
5.谷元兴，周莹珊，齐宝珠，蒋小武，李肖梁，方维焕*, 基于WIPI1分子自噬检测法及其在PCV2感染细胞自噬研究中的应用[J], 中国预防兽医学报，2016(07):537-541